The Institute for Systems Biology (ISB) is a nonprofit biomedical research organization based in Seattle.

ISB serves as the ultimate environment where scientific collaboration stretches across disciplines and across academic and industrial organizations, where our researchers have the intellectual freedom to challenge the status quo, and where grand visions for breakthroughs in human health inspire a collective drive to achieve the seemingly impossible. Our core values ensure that we always keep our focus on the big ideas that eventually will have the largest impact on human health.

ISB was founded in 2000 by systems biologist Leroy Hood and established on the belief that conventional models for exploring and funding breakthrough science have not caught up with the real potential of what is possible today. We are an affiliate of Providence St. Joseph Health, one of the largest nonprofit health care systems in the United States.

The people of ISB are becoming the leading experts in the function and behavior of every organ in the human body. Today we are poised to track the progression of human life in all its stages, to map how diseases are created and how they progress in our bodies, to better predict, prevent or diminish the effect of the entire range of human illnesses, to better understand the role environmental factors play, and to assure a longer, healthier life for all of humankind. ISB is literally at the epicenter of creating a new future for human health.

ISB is neither a classical definition of an academic organization nor is it a biotechnology company. We are unique. Unlike in traditional academic departments, our faculty are cross-disciplinary and work collaboratively toward a common vision. This cross-disciplinary approach enables us to take on big, complex problems. While we are vision-driven, ISB is also deeply committed to sharing that knowledge with society: We participate in the formation of companies, and strategically partner with industry to transfer technologies, products and new concepts generated by our ambitious projects.


“170+ full-time staff from 30 countries | 45 degree fields | 12 faculty members | 27 principal and senior research scientists & engineers |1600+ research publications since 2000 | 19 spinout companies | $445 million+ in grants & contracts revenue | $99 million+ in philanthropic contributions | 1000 K-12 science educators annually receive professional development & systems biology training”

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“We exist to make profound breakthroughs in human health,
leveraging the revolutionary potential of systems biology.”

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